LAG3 constrains anti-parasitic response by effector CD4+ T-cell in early Echinococcus multilocularis-infected mice
Our study reveals a previously unrecognized role for LAG3 as an immune checkpoint during early E. multilocularis infection, highlighting its function in limiting anti-parasitic CD4<sup>+</sup> T cell responses. Thus, while timed LAG3 blockade may represent a potential therapeutic strategy for AE, our data underscore the critical importance of stage-specific intervention to balance parasitic clearance with the control of fibrosis and tissue damage.
Authors
- Yi Gao (ORCID: https://orcid.org/0000-0002-3095-7888)
- Chuanshan Zhang (ORCID: https://orcid.org/0000-0002-3241-2224)
- Abidan Ainiwaer (ORCID: https://orcid.org/0000-0001-6516-9171)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Yinshi Li
- Wenge Liu
- Bingqing Deng
- Dewei Li
- Conghui Ge
- Na Tang
- Wenying Xiao
- Jing Li
- Sheng Sun
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s13071-026-07246-y
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00