External Evaluation of a Plasma and Cerebrospinal Fluid Population Pharmacokinetics Model of Meropenem in Infants.
The original NeoMero model performed reasonably well, and the proposed dosing regimens, that is, 20 or 40 mg/kg every 8 hours (12 hours if gestational age <32 weeks and postnatal age <2 weeks), depending on target MIC are estimated to achieve substantial bacterial killing in the CNS.
Authors
- Chi Dang Hornik (ORCID: https://orcid.org/0000-0002-7656-3657)
- James Lp
- Sarah G. Anderson (ORCID: https://orcid.org/0000-0002-2448-0446)
- Elkana Kohn (ORCID: https://orcid.org/0000-0003-0197-4440)
- Matitiahu Berkovitch (ORCID: https://orcid.org/0000-0001-9579-383X)
- Sitora Turdalieva
- Daniel K Benjamin
- Rachel G Greenberg
- Angelique E Boutzoukas
- Ngoc Betty Ngo
- Elizabeth H Payne
Institutions
- University of Liverpool (GB)
- Duke University (US)
- Clinical Research Institute (US)
- Assaf Harofeh Medical Center (IL)
- Emmes (United States) (US)
- University of Tartu (EE)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- PubMed
- Published
- 2026-02-01
- DOI
- https://doi.org/10.5863/jppt-25-00142
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00