From correlation to causation: cell‐type‐specific gene regulatory networks in Alzheimer's disease

Comprehensive causal regulatory maps across six brain cell types revealed cell-type-specific regulatory mechanisms that move beyond traditional correlation-based and TF-centric model limitations. Novel and established hub genes and functional modules were compared across cell types, providing insights into cellular functions related to AD. Hub gene roles as regulators or targets were quantitatively evaluated within cell-type GRNs. The constructed GRNs show upstream non-TF genes regulating TFs and interconnected TF regulatory modules, highlighting the complexity of AD regulatory mechanisms beyond TF-centric assumptions.