Effects of major solid cancer surgery on oxidative stress assessed by plasma xanthine oxidase and adenosine deaminase activity : a pilot study
Solid cancers were associated with elevated plasma expression of OS, which significantly decreased after surgery. However, major surgery itself induces a residual oxidative burden, reflected by an elevation in myocardial biomarkers. The increased levels of OS levels before surgery could fit the cancer-driven "priming/second-hit" framework. The negative correlation between ADA and XO suggests a potential feedback mechanism. These findings bring new insights regarding OS modulation during major solid cancer surgery and warrant further investigation in larger studies.
Authors
- Marion Marlinge (ORCID: https://orcid.org/0000-0001-5875-8760)
- D. Mokart
- Laurent Zieleskiewicz
- Nathalie Lalevée (ORCID: https://orcid.org/0000-0003-1924-1667)
- Amin Ben Lassoued
- Julien Fromonot (ORCID: https://orcid.org/0000-0001-6726-9125)
- David Jérémie Birnbaum (ORCID: https://orcid.org/0000-0002-9026-3044)
- Julia Dodivers
- Alex Thomas
- Bruno Pastene
- Régis Guieu
- Marc Leone
- Aissatou Pethwol Bah
Institutions
- Inserm (FR)
- Aix-Marseille Université (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Hôpital Nord (FR)
- Institut Paoli-Calmettes (FR)
- Hôpital de la Timone (FR)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s12957-026-04250-5
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00