Host Serum Biomarker Signatures in Mycobacteriologically Cured Pulmonary Tuberculosis Patients with Persistent Lung Inflammation on 18F-FDG PET/CT
We report associations between serum inflammatory mediators and persistent pulmonary inflammation following mycobacterial clearance in TB patients, highlighting their potential as diagnostic biomarkers that could potentially meet the target product profile (TPP) criteria.
Authors
- Reto Guler
- Antoneta Mashinyira
- Mümin Öztürk
- Muki Shey (ORCID: https://orcid.org/0000-0002-8776-4737)
- Friedrich Thienemann (ORCID: https://orcid.org/0000-0002-4801-2030)
- Solima Sabeel (ORCID: https://orcid.org/0000-0003-4200-8994)
- Bongani Motaung (ORCID: https://orcid.org/0000-0002-4416-8353)
- Sandra Mukasa (ORCID: https://orcid.org/0000-0003-3151-1383)
- Tessa Kotze (ORCID: https://orcid.org/0000-0001-5362-1781)
- Karen Wolmarans
- Trevor S Mafu
- Fareda Jakoet-Bassier
- Ashleigh Taylor
Institutions
- Western Cape Department of Health (ZA)
- University of Cape Town (ZA)
- University of Zurich (CH)
- International Centre for Genetic Engineering and Biotechnology (ZA)
- University Hospital of Zurich (CH)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
- Hirslanden Andreasklinik Cham Zug (CH)
Publication Details
- Journal
- Diseases
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3390/diseases14020070
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- University of Cape Town
- European and Developing Countries Clinical Trials Partnership