High‐intensity interval training induces lactate dehydrogenase B lactylation to inhibit hepatic lipogenesis to alleviate metabolic dysfunction‐associated fatty liver disease
HIIT effectively alleviates HFD-induced MAFLD in mice by regulating hepatic lactate metabolism to inhibit lactate-substrate DNL, and the ability of LDHB K82La to regulate LDHB activity may be one of the mechanisms by which HIIT exerts the above effects.
Authors
- Wenhua Huang (ORCID: https://orcid.org/0000-0003-2382-9180)
- Yingying Sun (ORCID: https://orcid.org/0000-0002-0788-7076)
- Zheng Xing (ORCID: https://orcid.org/0000-0003-0896-2733)
- Jie Qiong Su
- Shitian Li (ORCID: https://orcid.org/0000-0001-6342-2698)
- Yanjun Li (ORCID: https://orcid.org/0000-0002-3739-7553)
- George Zhang (ORCID: https://orcid.org/0000-0003-2073-7109)
- Lanlan Guo
- Xuefei Chen
- Fengyi Li
Institutions
- University of International Business and Economics (CN)
- Beijing Normal University (CN)
- Zhengzhou University (CN)
- Zhengzhou University of Science and Technology (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1111/dom.70543
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University
- National Office for Philosophy and Social Sciences