Six-Week Changes in Pain Biomarkers Following Reverse Total Shoulder Arthroplasty: A Prospective Cohort Study
Pain intensity, location, nature, and mechanism can serve as biomarkers of the short-term postsurgical changes that can be expected following rTSA. Baseline pain intensity and temporal summation magnitude of the tibialis anterior were associated with the degree of pain improvement, suggesting their use for preoperative risk assessment. Future research should evaluate whether these 6-week biomarker changes are associated with the development of chronic postoperative pain at longer durations after surgery.
Authors
- Jason Zafereo (ORCID: https://orcid.org/0000-0003-2190-9216)
- Bansari Dilipkumar Thakkar
- Cassie M. Argenbright (ORCID: https://orcid.org/0009-0004-3964-9496)
- Andrew J. Nasr (ORCID: https://orcid.org/0000-0001-9954-753X)
- Alison Cabrera
- Chris Pierson
- Tracy L. Greer (ORCID: https://orcid.org/0000-0002-3546-5292)
- Khosrow Bebehani
Institutions
- St. Jude Children's Research Hospital (US)
- Texas Woman's University (US)
- The University of Texas at Arlington (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-12
- DOI
- https://doi.org/10.64898/2026.02.10.26346010
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Texas Southwestern Medical Center
- University of Texas at Arlington
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Center for Advancing Translational Sciences