Early brain radiotherapy combined with third-generation EGFR-TKIs improves survival in EGFR-mutant NSCLC with synchronous brain metastases: a multi-center retrospective analysis

For patients with EGFR-mutant NSCLC and synchronous BM, early brain radiotherapy combined with first-line third-generation EGFR-TKIs is associated with significantly improved intracranial control and overall survival compared to deferring radiotherapy until progression, without a significant increase in severe toxicity. These findings support consideration of an early integrated treatment approach.