Unveiling FLNC variants: iPSC-derived myogenic cells as a model to study disease mechanisms
Our model is suitable to monitor aspects of filaminopathies' pathogenesis and to investigate possible therapeutic interventions with quantitative readouts.
Authors
- Felix Kleefeld (ORCID: https://orcid.org/0000-0002-0643-7313)
- Lampros Mavrommatis (ORCID: https://orcid.org/0009-0001-6826-8068)
- Nassam Daya (ORCID: https://orcid.org/0000-0003-1492-5621)
- Karsten Krause
- Anne Schänzer (ORCID: https://orcid.org/0000-0002-2014-2028)
- Dominik Sellung
- Holm Zaehres (ORCID: https://orcid.org/0000-0001-8062-8428)
- Anne-Katrin Guettsches
- Jaqueline C. Kinold
- L. Volke
- Anja Schreiner
- Tobias Ruck
- Hanna Schlierbach
- Andreas Hentschel
- Christopher Nelke
- Nicolina Suedkamp
- Andreas Roos
- Marie-Cecile Kienitz
- Matthias Vorgerd
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Children's Hospital of Eastern Ontario (CA)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Düsseldorf University Hospital (DE)
- Leibniz Institute for Analytical Sciences - ISAS (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Duisburg-Essen (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s13395-026-00418-5
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00