Medical device-based neuromodulation for motor symptoms in Parkinson’s disease: a systematic review and meta-analysis
MDBN is associated with modest yet significant motor improvements in PD. Effect size estimates are influenced by methodological characteristics, particularly analysis strategy and comparator selection. This is the first review in the field to calculate and incorporate separate effect sizes for each active intervention group in multi-arm trials, enabling more precise data inclusion.
Authors
- W. A. MORAES
- F. Fregni
- Jamie Perin (ORCID: https://orcid.org/0000-0002-5482-6620)
- Elly Pichardo
- Tim Wagner
- Joao Victor Ribeiro (ORCID: https://orcid.org/0009-0002-7309-918X)
- Laura Dipietro
- Paulo E. P. Teixeira
- Ciro Ramos-Estebanez
Institutions
- Harvard University (US)
- Universidade de São Paulo (BR)
- Spaulding Rehabilitation Hospital (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- University of Chicago Medical Center (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Highland Community College - Illinois (US)
- Faculdade São Leopoldo Mandic (BR)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fneur.2026.1731885
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke