High vulnerability of medial prefrontal pyramidal neurons in post‐stroke, vascular, Alzheimer's disease, and aging‐related dementias
Severe pyramidal neuron loss and atrophy arose in the medial prefrontal cortex. Neuronal morphometric changes correlated with cognitive status or aging effects. Metabolic changes decreased by the greatest extent in vascular-associated dementias. Metabolic neuronal markers correlated with aging and frontal vascular pathology.
Authors
- Ahmad A. Khundakar (ORCID: https://orcid.org/0000-0002-4835-5359)
- Lauren Walker (ORCID: https://orcid.org/0000-0001-8281-8938)
- Dan Jobson (ORCID: https://orcid.org/0000-0003-1151-4827)
- Yoshiki Hase (ORCID: https://orcid.org/0000-0002-9538-905X)
- Raj N Kalaria
Institutions
- University of Exeter (GB)
- Newcastle Hospitals - Campus for Ageing and Vitality (GB)
- Teesside University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71151
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Society
- National Institute for Health and Care Research
- Newcastle University
- Medical Research Council
- NIHR Newcastle Biomedical Research Centre