L-kynurenine reshapes immune microenvironment to alleviate methamphetamine-induced chronic lung injury through gut-lung axis
From the perspective of intestinal microbiome-metabolite-immune network regulation, the omics characteristic factor L-KYN reshaped the immune microenvironment and alleviated methamphetamine-induced chronic lung injury through the gut-lung axis, providing a new theoretical and experimental basis for the prevention and treatment of MA-induced chronic lung injury. Video Abstract.
Authors
- Weiting Hu
- Lie Chen (ORCID: https://orcid.org/0000-0001-9764-4299)
- Yang Ding (ORCID: https://orcid.org/0000-0002-5102-1157)
- Ying Pan (ORCID: https://orcid.org/0000-0002-9477-5119)
- Yun Wang
- Pei-Jun Ma
- Ming Li
- Xin Wang
- Ye-Kui Liang
Institutions
- Shenyang Medical College (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s40168-026-02348-2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00