Use of Clinical Notes to Assess Neuropsychiatric Events After Montelukast Initiation
This cohort study found that clinical information from linked claims and structured and unstructured EHR data was associated with enriched measurement of patient and disease characteristics and enhanced completeness of evidence vs claims data alone. The findings, however, did not differ substantially across the incrementally contributing data sources or from prior studies. Drug safety and effectiveness studies should integrate information using clinical notes from EHRs with consideration of potential limitations, challenges, and necessary validation processes.
Authors
- Rishi Desai (ORCID: https://orcid.org/0000-0003-0299-7273)
- Kimberly J. Dandreo (ORCID: https://orcid.org/0000-0003-2332-1969)
- Olga Guijon
- Lior Seluk (ORCID: https://orcid.org/0000-0003-0127-6626)
- Louis Ehwerhemuepha (ORCID: https://orcid.org/0000-0003-1369-7954)
- Michael M. Chu
- Dena H. Jaffe
- Sarah K. Dutcher (ORCID: https://orcid.org/0000-0003-0574-2890)
- Jummai Apata (ORCID: https://orcid.org/0000-0001-6733-6914)
- Elise Berliner
- Jamal Jones (ORCID: https://orcid.org/0000-0002-2709-0806)
- Jie Li (ORCID: https://orcid.org/0000-0002-7534-7389)
- Sengwee Toh
- Kyla Finlayson
- Jenna Wong
- Austin Yue
- Yong Ma
- Michael E. Wechsler
Institutions
- Brigham and Women's Hospital (US)
- Children's Hospital of Orange County (US)
- United States Food and Drug Administration (US)
- Center for Drug Evaluation and Research (US)
- Harvard University (US)
- University of California, Irvine (US)
- National Jewish Health (US)
- Oracle (Israel) (IL)
- Harvard Pilgrim Health Care (US)
- Kansas City Area Life Sciences Institute (US)
- University of Missouri–Kansas City (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.58433
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00