Subcutaneous Granuloma Annulare in a Middle-Aged Patient: A Case Report

Subcutaneous granuloma annulare (SGA) is a rare, benign variant of granuloma annulare, typically seen in children, which presents as asymptomatic subcutaneous nodules with normal overlying skin. The etiology remains unclear despite associations with systemic disease such as diabetes mellitus. Clinicopathologic correlation is crucial to accurate diagnosis. In this report, we present a case of a 53-year-old female patient with tender, bilateral subcutaneous nodules on her elbows. Punch biopsy confirmed the diagnosis of granuloma annulare. The primary management for her condition at the time was focused on observation and conservative care. However, secondary management with intralesional injection of triamcinolone was utilized when her lesions recurred after a window of resolution. Our case highlights an interesting manifestation of granuloma annulare and demonstrates the importance of both clinical and histological evaluation in distinguishing between similar presenting differential diagnoses. Successful treatment is heavily dependent on accurate diagnosis and patients should be monitored for complete resolution.

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Publication Details

Journal
Cureus
Published
2026-02-12
DOI
https://doi.org/10.7759/cureus.103506
Primary Topic
Skin Diseases and Diabetes
Type
article
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article

Subcutaneous Granuloma Annulare in a Middle-Aged Patient: A Case Report

Douglas J. Grider, Raj Patel, Padma V Chitnavis, Yao Liang
Cureus
Skin Diseases and Diabetes
article

Subcutaneous Granuloma Annulare in a Middle-Aged Patient: A Case Report

Douglas J. Grider, Raj Patel, Padma V Chitnavis, Yao Liang
article en

Abstract

Subcutaneous granuloma annulare (SGA) is a rare, benign variant of granuloma annulare, typically seen in children, which presents as asymptomatic subcutaneous nodules with normal overlying skin. The etiology remains unclear despite associations with systemic disease such as diabetes mellitus. Clinicopathologic correlation is crucial to accurate diagnosis. In this report, we present a case of a 53-year-old female patient with tender, bilateral subcutaneous nodules on her elbows. Punch biopsy confirmed the diagnosis of granuloma annulare. The primary management for her condition at the time was focused on observation and conservative care. However, secondary management with intralesional injection of triamcinolone was utilized when her lesions recurred after a window of resolution. Our case highlights an interesting manifestation of granuloma annulare and demonstrates the importance of both clinical and histological evaluation in distinguishing between similar presenting differential diagnoses. Successful treatment is heavily dependent on accurate diagnosis and patients should be monitored for complete resolution.

CureusVol. 18(2)
University of South Florida (US), Carilion Roanoke Memorial Hospital (US), Carilion Clinic (US), Virginia Tech (US), Edward Via College of Osteopathic Medicine (US)
Gender equality, Good health and well-being
Openalex Percentile: Top 57%
Skin Diseases and Diabetes
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