NCF2 facilitates M2 macrophage polarization in glioblastoma through activation of the notch1–osteopontin axis
NCF2 contributes to the establishment of an immunosuppressive tumor microenvironment in GBM by promoting macrophage polarization via the Notch1-OPN pathway. These findings highlight NCF2 as a potential molecular target for therapeutic intervention in GBM.
Authors
- Yinsong Zhang
- Yi Xiang (ORCID: https://orcid.org/0000-0002-8728-8451)
- Na Li (ORCID: https://orcid.org/0009-0001-8624-0114)
- Hongbo Cheng
- Guozhu Sun
Institutions
- Hebei Medical University (CN)
- Hengshui University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fimmu.2026.1743950
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province