Alleviation of nitroglycerin-induced migraine in rats: inhibition of central sensitization by optimizing Qinggan Jieyu decoction regulation of purinergic receptor P2X ligand-gated ion channel 7 and autophagy.

QGJY alleviates migraine and inhibits central sensitization in rats, potentially by downregulating P2X7R expression, concomitantly suppressing autophagy, attenuating microglial activation, and reducing pro-inflammatory cytokine release.

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Publication Details

Journal
PubMed
Published
2026-02-01
DOI
https://doi.org/10.19852/j.cnki.jtcm.2026.01.008
Primary Topic
Migraine and Headache Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Alleviation of nitroglycerin-induced migraine in rats: inhibition of central sensitization by optimizing Qinggan Jieyu decoction regulation of purinergic receptor P2X ligand-gated ion channel 7 and autophagy.

Jiazheng LI, Bo Zhou
PubMed
Migraine and Headache Studies
article

Alleviation of nitroglycerin-induced migraine in rats: inhibition of central sensitization by optimizing Qinggan Jieyu decoction regulation of purinergic receptor P2X ligand-gated ion channel 7 and autophagy.

Jiazheng LI, Bo Zhou
article en

Abstract

QGJY alleviates migraine and inhibits central sensitization in rats, potentially by downregulating P2X7R expression, concomitantly suppressing autophagy, attenuating microglial activation, and reducing pro-inflammatory cytokine release.

PubMedVol. 46(1)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Xiyuan Hospital (CN)
Good health and well-being
Openalex Percentile: Top 61%
Migraine and Headache Studies
DOIOpen Access PDFOpenAlex
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Alleviation of nitroglycerin-induced migraine in rats: inhibition of central sensitization by optimizing Qinggan Jieyu decoction regulation of purinergic receptor P2X ligand-gated ion channel 7 and autophagy. — Jiazheng LI, Bo Zhou · PubMed (2026) | TGRS Research Map | TGRS