Long-term follow-up of autoimmune polyendocrine syndrome type 1 in Norway
APS-1 should be considered in patients diagnosed with PAI before age 20, and AIRE sequencing is recommended for diagnostic confirmation. The presence of IFN-ω autoantibodies, a pro-inflammatory cytokine profile, and increased soluble IFN receptor levels further support the role of dysregulated interferon responses in APS-1 pathogenesis.
Authors
- A Bakke (ORCID: https://orcid.org/0000-0002-7069-6870)
- Marthe Landsverk Rensvik
- Lars Breivik (ORCID: https://orcid.org/0000-0003-2889-7342)
- Ingrid Nermoen
- Bergithe E Oftedal (ORCID: https://orcid.org/0000-0003-4248-7737)
- Husebye Es
- Mihaela Cuida Marthinussen (ORCID: https://orcid.org/0000-0001-6163-4339)
- Trine Finnes (ORCID: https://orcid.org/0000-0003-1102-8706)
- Anders Palmstrøm Jørgensen (ORCID: https://orcid.org/0000-0002-1246-9194)
- Thea Sjøgren
- Anette S. B. Wolff (ORCID: https://orcid.org/0000-0002-8485-2248)
- Bjørn Gunnar Nedrebø (ORCID: https://orcid.org/0000-0003-1635-8325)
- Hallvard Singsås
- Isil Kucuka (ORCID: https://orcid.org/0000-0001-9286-8437)
- Guri Grimnes
- Kari Lima
- Cecilie Gjerde
- Margrethe Svendsen
- Marianne Grytaas
- Marianne Øksnes
- Eirik Bratland
Institutions
- Oslo University Hospital (NO)
- University Hospital of North Norway (NO)
- University of Oslo (NO)
- Innlandet Hospital Trust (NO)
- Stavanger University Hospital (NO)
- Akershus University Hospital (NO)
- Haukeland University Hospital (NO)
- Privatsykehuset Haugesund (NO)
- Molde Hospital (NO)
- Graz University Hospital (AT)
- Ålesund Hospital (NO)
- St Olav's University Hospital (NO)
- Western Norway University of Applied Sciences (NO)
- University of Bergen (NO)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1210/clinem/dgag060
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00