Association between peripheral IFN-γ+ cytotoxic lymphocytes and response to PD-1/PD-L1-based therapy in hepatocellular carcinoma
These findings support peripheral IFN-γ<sup>+</sup> cytotoxic lymphocytes as a candidate noninvasive biomarker for stratifying HCC patients receiving PD-1/PD-L1-based therapy.
Authors
- Hui Lü (ORCID: https://orcid.org/0000-0002-5921-1043)
- Q. Edward Wang (ORCID: https://orcid.org/0009-0001-8333-2689)
- Wenwen Liu (ORCID: https://orcid.org/0000-0002-5254-4187)
- Mengqi Ruan (ORCID: https://orcid.org/0009-0005-2103-831X)
- Huijuan Fang (ORCID: https://orcid.org/0000-0002-4081-0150)
- Yan Wang
- Qiang Zhou
- Zhi Duang
Institutions
- Anhui Medical University (CN)
- Beike Biotechnology (China) (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fimmu.2026.1738116
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Medical University
- Key Research and Development Projects of Shaanxi Province