Albumin-Keratin Casts Obstruct Renal Tubular and Vascular Lumens Following Kidney Ischemia
Our data indicate that albumin-keratin casts obstruct both vascular and tubular structures in the kidney following a period of ischemia. These casts may be the primary cause of vascular obstruction post-ischemia and likely lead to RBC trapping and associated acute tubular injury.
Authors
- Carlee Harris
- Wendy B. Bollag (ORCID: https://orcid.org/0000-0003-3146-162X)
- M. Bryant
- David L. Mattson (ORCID: https://orcid.org/0000-0002-5401-0269)
- Aaron J. Polichnowski (ORCID: https://orcid.org/0000-0003-0347-663X)
- Sarah R. McLarnon (ORCID: https://orcid.org/0000-0002-5082-7626)
- Sadaf Husan
- Oliver Oglesby
- Amanda Barrett
- Jingping Sun
- Paul M. O’Connor
- Brendan Marshall
- Olivia Mosley
- Angela Ajith
- Daniela Dokam
- Olivia Boykin
Institutions
- University of North Carolina at Chapel Hill (US)
- East Tennessee State University (US)
- Augusta University (US)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1016/j.ekir.2026.106356
- Primary Topic
- Skin and Cellular Biology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00