Intergenerational Conditioning via Intermittent Parental Hypoxia Confers Stroke Resilience in Offspring
Intermittent hypoxia in parents acts as an intergenerational conditioning stimulus, conferring offspring resilience to stroke. This neuroprotective phenotype is supported by coordinated molecular adaptations in key pathways involved in survival and stress response. These findings highlight the potential for parental environmental conditioning to shape stroke outcomes in offspring, opening new avenues for therapeutic exploration.
Authors
- Nilay Ateş
- Aysun Çağlayan (ORCID: https://orcid.org/0000-0002-2657-3515)
- Ertuğrul Kilic
- Serdar Altunay (ORCID: https://orcid.org/0000-0002-4051-2559)
- Mustafa Çağlar Beker (ORCID: https://orcid.org/0000-0002-9476-8488)
- Milena De Felice (ORCID: https://orcid.org/0000-0001-5729-6525)
- Favour Felix-Ilemhenbhio (ORCID: https://orcid.org/0000-0002-5371-5400)
- Ahmet B. Çağlayan (ORCID: https://orcid.org/0000-0002-6242-3709)
- Ok-Nam Bae
- David Burrows (ORCID: https://orcid.org/0000-0002-5833-9379)
- Enes Doğan (ORCID: https://orcid.org/0009-0009-3039-8826)
- Professor Arshad Majid
- Ali N. Ali
- Hayriye E. Yelkenci
Institutions
- University of Michigan (US)
- Istanbul Medipol University (TR)
- Michigan Medicine (US)
- Hanyang University (KR)
- Istanbul Medeniyet University (TR)
- University of Sheffield (GB)
Publication Details
- Journal
- Stroke
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1161/strokeaha.125.052885
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00