Predictive value of natural killer (NK) cells in bone marrow for relapse in diffuse large B cell lymphoma: integrating antibody-dependent cell-mediated cytotoxicity (ADCC)-based immunotherapy
Patients with higher NK cell percentages may better tolerate chemotherapy-induced depletion, thereby preserving or restoring their effector pool more efficiently. Elevated bone marrow NK cell percentages predict favorable outcomes in DLBCL and support their potential role as translational biomarkers. Incorporating NK cell monitoring into clinical protocols could improve risk stratification and guide immunotherapeutic strategies for personalized patient management.
Authors
- Puy Garrastachu (ORCID: https://orcid.org/0000-0001-5344-0737)
- Ada Esteban-Figuerola (ORCID: https://orcid.org/0000-0002-4590-0999)
- Andrea Campeny-Nájara
- E. Ruiz de Gaona
- Juan Cabello (ORCID: https://orcid.org/0000-0002-3835-0116)
- Javier Larreina-Pérez
- Ricardo Garcı́a-Muñoz (ORCID: https://orcid.org/0000-0003-3201-3909)
- Sofía Rincón-López (ORCID: https://orcid.org/0009-0009-8972-7006)
- Johelys Atencio-Matos
- M. Velasco‐Ruiz
- Isabel García-Bosque
- Alfonso Martín-Carnicero
- Jesús Feliu
- Olalla Pereda-Sainz
- Carmen Rodriguez-Lefler
- Montserrat Hernandez-Perez
Institutions
- Diasa Industrial (Spain) (ES)
- Hospital San Pedro (ES)
- Center for Biomedical Research of La Rioja (ES)
- Hospital General de La Rioja (ES)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1007/s00262-026-04322-1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00