Tumor-derived Extracellular Vesicles Induce ER Stress to Drive Tolerogenic Dendritic Cell Development in the Tumor Microenvironment
Tumor EVs contribute to the development and pro-tolerogenic function of mregDCs in the TME by triggering the UPR pathway. Aberrant lipid metabolism involving enhanced FAO are common characteristics associated with DC dysfunction in the TME. Strategies to interrupt these pathways represent promising approaches for reversing immune tolerance and enhancing tumor-targeted CD8 <sup>+</sup> T cell responses.
Authors
- Brent Allen Hanks (ORCID: https://orcid.org/0000-0002-2803-3272)
- Y‐Van Nguyen (ORCID: https://orcid.org/0000-0003-1888-2147)
- X F Wang (ORCID: https://orcid.org/0009-0007-5226-5632)
- Michael Sturdivant (ORCID: https://orcid.org/0000-0002-0729-2275)
- Michael P. Plebanek (ORCID: https://orcid.org/0000-0002-4966-5199)
- Mahere Razazade Bazaz
- Balamayooran Theivanthiran
Institutions
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-02-12
- DOI
- https://doi.org/10.64898/2026.02.10.705213
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00