Transthyretin Amyloid May Drive Fibrosis and Proliferation of Tenosynovial Fibroblasts in Carpal Tunnel Syndrome

CTS with TTR deposition may reflect more than a localized neuropathy, as TTR potentially plays a pathogenic role in CTS development. This finding provides novel insights into the underlying mechanisms of CTS.

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Publication Details

Journal
Journal of Bone and Joint Surgery
Published
2026-02-12
DOI
https://doi.org/10.2106/jbjs.25.00807
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

Transthyretin Amyloid May Drive Fibrosis and Proliferation of Tenosynovial Fibroblasts in Carpal Tunnel Syndrome

Yoshitaka Tsujimura, Yoshiaki Yamanaka, Naohito Sato, Manabu Tsukamoto et al.
Journal of Bone and Joint Surgery
Amyloidosis: Diagnosis, Treatment, Outcomes
article

Transthyretin Amyloid May Drive Fibrosis and Proliferation of Tenosynovial Fibroblasts in Carpal Tunnel Syndrome

Yoshitaka Tsujimura, Yoshiaki Yamanaka, Naohito Sato, Manabu Tsukamoto, Toichiro Naito, Yukichi Zenke, Hitoshi Suzuki, Akinori Sakai
article en

Abstract

CTS with TTR deposition may reflect more than a localized neuropathy, as TTR potentially plays a pathogenic role in CTS development. This finding provides novel insights into the underlying mechanisms of CTS.

Journal of Bone and Joint Surgery
University of Occupational and Environmental Health Japan (JP)
Openalex Percentile: Top 59%
Amyloidosis: Diagnosis, Treatment, Outcomes
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