The function and mechanism of LINC01583 on Osimertinib resistance in non-small cell lung cancer
In this study, we revealed LINC01583 as a key oncogenic driver that promotes both NSCLC progression and Osi resistance by functioning as a competing endogenous RNA (ceRNA) for miR-4640-5p, thereby upregulating its target gene CHD8.
Authors
- Shu Xu (ORCID: https://orcid.org/0000-0003-4608-8610)
- Ting Xu (ORCID: https://orcid.org/0000-0002-0172-9683)
- Liu Na (ORCID: https://orcid.org/0000-0003-0751-500X)
- X. Wang
Institutions
- Nanjing Brain Hospital (CN)
- Nanjing Chest Hospital (CN)
Publication Details
- Journal
- Molecular and Cellular Probes
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.mcp.2026.102067
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00