Fibrin sealant for prophylaxis of cervical anastomotic leakage after McKeown esophagectomy for esophageal or esophagogastric junction cancer (PLACE030): a Phase III multicenter randomized clinical trial

Intraoperative sealing with porcine FS did not significantly reduce the incidence of cervical AL. For patients who undergo upfront esophagectomy, the potential protective effect of FS needs further studies.

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Publication Details

Journal
International Journal of Surgery
Published
2026-02-12
DOI
https://doi.org/10.1097/js9.0000000000004514
Primary Topic
Hemostasis and retained surgical items
Type
article
Field-Weighted Citation Impact
0.00
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article

Fibrin sealant for prophylaxis of cervical anastomotic leakage after McKeown esophagectomy for esophageal or esophagogastric junction cancer (PLACE030): a Phase III multicenter randomized clinical trial

Caiyan Fang, G. Wang, Ze-Rui Zhao, Shaobin Chen et al.
International Journal of Surgery
Hemostasis and retained surgical items
article

Fibrin sealant for prophylaxis of cervical anastomotic leakage after McKeown esophagectomy for esophageal or esophagogastric junction cancer (PLACE030): a Phase III multicenter randomized clinical trial

Caiyan Fang, G. Wang, Ze-Rui Zhao, Shaobin Chen, Sharvesh Raj Seeruttun, Jiahui Wu, Jian‐Bin Li, Wenqiang Lv, Weizhao Huang, Chenghao Wang, T. Mao, Zhichao Li, Jiyang Chen, H Yang, Yu Yang, Lin Peng, Yi Liang, Weidong Wang, Sheng Huang, Huilin Su, Bin Li, Yan Huang
article en

Abstract

Intraoperative sealing with porcine FS did not significantly reduce the incidence of cervical AL. For patients who undergo upfront esophagectomy, the potential protective effect of FS needs further studies.

International Journal of Surgery
Sun Yat-sen University (CN), Shanghai Chest Hospital (CN), Shantou University (CN), Cancer Hospital of Shantou University Medical College (CN), Zhongshan People's Hospital (CN), Sichuan Cancer Hospital (CN), Lanzhou University Second Hospital (CN), Zhongshan Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Sun Yat-sen University Cancer Center (CN), Lanzhou University (CN)
Good health and well-being
Openalex Percentile: Top 57%
Hemostasis and retained surgical items
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Fibrin sealant for prophylaxis of cervical anastomotic leakage after McKeown esophagectomy for esophageal or esophagogastric junction cancer (PLACE030): a Phase III multicenter randomized clinical trial — Caiyan Fang, G. Wang, et al. · International Journal of Surgery (2026) | TGRS Research Map | TGRS