Progressive iron deposition and widespread neural dysfunction in Parkinson’s disease: a multimodal MRI study

Building on established evidence that PD involves progressive iron deposition in the SN and GP and widespread neural network dysfunction, our multimodal MRI findings demonstrate that integrating ReHo, fALFF, and QSM provides a framework for characterizing stage-specific pathophysiological changes and support their potential as biomarkers for early diagnosis, disease staging, and therapeutic development.

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Publication Details

Journal
Quantitative Imaging in Medicine and Surgery
Published
2026-02-13
DOI
https://doi.org/10.21037/qims-2025-2070
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Progressive iron deposition and widespread neural dysfunction in Parkinson’s disease: a multimodal MRI study

Wei Wei, Kaixin Li, Hongxia Xin, Xinhui Wang et al.
Quantitative Imaging in Medicine and Surgery
Parkinson's Disease Mechanisms and Treatments
article

Progressive iron deposition and widespread neural dysfunction in Parkinson’s disease: a multimodal MRI study

Wei Wei, Kaixin Li, Hongxia Xin, Xinhui Wang, Yu Shen, Bo Wu, Yan Bai, E. Mark Haacke, Shuo Liu, Meiyun Wang
article en

Abstract

Building on established evidence that PD involves progressive iron deposition in the SN and GP and widespread neural network dysfunction, our multimodal MRI findings demonstrate that integrating ReHo, fALFF, and QSM provides a framework for characterizing stage-specific pathophysiological changes and support their potential as biomarkers for early diagnosis, disease staging, and therapeutic development.

Quantitative Imaging in Medicine and SurgeryVol. 16(3)
Wayne State University (US), Zhengzhou University (CN), Henan Academy of Sciences (CN), Henan Provincial People's Hospital (CN), Siemens (China) (CN), Henan Medical University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 61%
Parkinson's Disease Mechanisms and Treatments
DOIOpen Access PDFOpenAlex
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Progressive iron deposition and widespread neural dysfunction in Parkinson’s disease: a multimodal MRI study — Wei Wei, Kaixin Li, et al. · Quantitative Imaging in Medicine and Surgery (2026) | TGRS Research Map | TGRS