Serotonin transporter downregulation is associated with aortic stenosis, and early profibrotic remodeling is mitigated by pharmacological inhibition of HTR2B receptor
In human and mouse AVs, reduced SERT expression and increased HTR2B signaling contribute to early-onset fibro-calcific remodeling. HTR2B inhibition by LY272015 reverses these effects, suggesting it as a potential therapeutic strategy for fibrotic remodeling in AS.
Authors
- Ayanna Campbell
- C. Camillo
- Dov Levine (ORCID: https://orcid.org/0000-0003-1675-0116)
- Erfan Faridmoayer (ORCID: https://orcid.org/0000-0003-0163-3881)
- Giovanni Ferrari (ORCID: https://orcid.org/0000-0002-8863-2496)
- Yaagnik Kosuri (ORCID: https://orcid.org/0000-0001-8767-2165)
- Abba Μ. Krieger (ORCID: https://orcid.org/0000-0002-4296-1278)
- Mark A. Oyama (ORCID: https://orcid.org/0000-0002-5218-9226)
- Estíbaliz Castillero (ORCID: https://orcid.org/0000-0002-2213-5809)
- Emre Bektik (ORCID: https://orcid.org/0000-0002-3558-2886)
- Cary Karcher
- Robert J. Levy
- Juan B. Grau
- Nicole Zeak
- Ting Peng
- Liming Pei
Institutions
- Valve (United States) (US)
- Columbia University Irving Medical Center (US)
- Valley Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fcvm.2026.1729078
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Hospital of Philadelphia
- Andrew Sabin Family Foundation
- National Institutes of Health
- Irving Medical Center, Columbia University
- Mega-projects of Science Research for the 10th Five-Year Plan
- National Heart, Lung, and Blood Institute