Comparison of the performance of large language models in answering patient questions related to cataract

This study evaluated the performance of four popular large-scale language models (ChatGPT o3-mini, Gemini 2.0 pro experimental, Deep Seek Thinking R1, and Kimi Thinking K1.5) in addressing frequently asked patient questions about cataracts and cataract surgery in Chinese. DeepSeek Thinking R1 performed comparably to Gemini 2.0 pro experimental in accuracy, while outperforming both ChatGPT o3-mini and Kimi Thinking K1.5. In terms of completeness and consistency, DeepSeek Thinking R1 showed superior performance over the other three LLMs. Regarding legibility and safety, DeepSeek Thinking R1, Gemini 2.0 pro experimental, and ChatGPT o3-mini exhibited comparable results, all performing better than Kimi Thinking K1.5. Deep Seek Thinking R1 demonstrated the strongest overall performance among the four LLMs in this comparative evaluation. The modern LLMs are promising tools for public education in ophthalmology while human oversight is still required.

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Publication Details

Journal
iScience
Published
2026-02-12
DOI
https://doi.org/10.1016/j.isci.2026.115002
Primary Topic
Machine Learning in Healthcare
Type
article
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article

Comparison of the performance of large language models in answering patient questions related to cataract

Jiayi Shi, Yuanfeng Jiang, Shaochong Bu, Fang Tian et al.
iScience
Machine Learning in Healthcare
article

Comparison of the performance of large language models in answering patient questions related to cataract

Jiayi Shi, Yuanfeng Jiang, Shaochong Bu, Fang Tian, Xinyi Liu, Qing He
article en

Abstract

This study evaluated the performance of four popular large-scale language models (ChatGPT o3-mini, Gemini 2.0 pro experimental, Deep Seek Thinking R1, and Kimi Thinking K1.5) in addressing frequently asked patient questions about cataracts and cataract surgery in Chinese. DeepSeek Thinking R1 performed comparably to Gemini 2.0 pro experimental in accuracy, while outperforming both ChatGPT o3-mini and Kimi Thinking K1.5. In terms of completeness and consistency, DeepSeek Thinking R1 showed superior performance over the other three LLMs. Regarding legibility and safety, DeepSeek Thinking R1, Gemini 2.0 pro experimental, and ChatGPT o3-mini exhibited comparable results, all performing better than Kimi Thinking K1.5. Deep Seek Thinking R1 demonstrated the strongest overall performance among the four LLMs in this comparative evaluation. The modern LLMs are promising tools for public education in ophthalmology while human oversight is still required.

iScienceVol. 29(3)
Tiangong University (CN), Tianjin Medical University Eye Hospital (CN), Tianjin Medical University (CN)
Quality Education
Openalex Percentile: Top 60%
Machine Learning in Healthcare
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