The effect of glutamatergic modulators on sleep behavior and architecture in depressive disorders: A systematic review
Our findings indicate that glutamatergic modulators, primarily ketamine, are associated with improvement across several sleep behaviors commensurate in MDD, suggesting that mechanisms subserving sleep are potential targets for depression treatment.
Authors
- Hana Ballum (ORCID: https://orcid.org/0009-0005-4064-5588)
- M Cheng
- William Cheung
- Christine E. Dri
- Rodrigo Mansur
- Gia Han Le
- Kayla M. Teopiz
- Kyle Valentino
- Heidi Ka Ying Lo
- Angela T.H. Kwan
- Joshua D. Rosenblat
- Bianca Shen
- Sabrina Wong
- Roger S. McIntyre
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Hong Kong Virtual University (CN)
- Brain and Cognition Discovery Foundation (CA)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Psychiatric Research
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.jpsychires.2026.02.011
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00