Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect
These results show that short-duration, moderate-amplitude stretching reduces tumor growth in several different animal models. We also provide evidence that this beneficial effect may be a direct mechanical effect on local matrix properties and tumor cell invasiveness.
Authors
- Mazen Mezher
- Hélène M. Langevin (ORCID: https://orcid.org/0000-0002-3142-1671)
- Paola Jurado Pérez
- Daniel Martı́n (ORCID: https://orcid.org/0000-0002-8880-9087)
- Oscar D. Safairad
- Andrew D. Doyle (ORCID: https://orcid.org/0000-0003-4150-5155)
- Yi He (ORCID: https://orcid.org/0000-0002-6884-5312)
- Rebecca D. Thompson
- Alexander X. Cartagena‐Rivera (ORCID: https://orcid.org/0000-0001-6227-2499)
- Gary J. Badger
- Chandra Bhan
- Lisbeth Berrueta
Institutions
- National Institutes of Health (US)
- University of Vermont Medical Center (US)
- National Institute of Biomedical Imaging and Bioengineering (US)
- National Institute of Dental and Craniofacial Research (US)
Publication Details
- Journal
- BMC Biology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s12915-026-02543-5
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00