Weight Regain after Lifestyle Interventions is Associated with Higher Risk of Liver Inflammation: A Retrospective Observational Study
Weight regain after lifestyle-induced weight loss is associated with early liver-related biochemical abnormalities and hepatic innate immune activation in the absence of advanced fibrosis, underscoring the need for early liver risk assessment in individuals with weight cycling.
Authors
- Miaomiao Yuan (ORCID: https://orcid.org/0000-0003-2477-9066)
- Shaoqian Zhao (ORCID: https://orcid.org/0009-0000-7701-5305)
- J. Wang
- Jie Hong (ORCID: https://orcid.org/0009-0005-9293-5114)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Yuyao Zou
- Zhiwen Cao
- Weiqiong Gu
- Zhenxi Zhang
Institutions
- Shanghai Jiao Tong University (CN)
- National Health and Family Planning Commission (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/dmso.s573217
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- Ruijin Hospital
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China