New-Onset Nonarteritic Anterior Ischemic Optic Neuropathy and Initiators of Semaglutide in US Veterans With Type 2 Diabetes
In this nationwide cohort of US veterans with T2D, semaglutide initiators had a 2-fold NAION risk than SGLT2i initiators, while the absolute risk was low. Clinicians and patients should be counseled on the rare but evident increased risk of NAION after semaglutide initiation.
Authors
- Kent Heberer (ORCID: https://orcid.org/0000-0003-2537-4335)
- Steven Cogill
- Jennifer Lee (ORCID: https://orcid.org/0000-0001-8119-2427)
- Ana I. Maldonado (ORCID: https://orcid.org/0000-0002-7247-3363)
- Julie Lynch
- A. Bress
- Ying Q. Chen
- Sun H. Kim
- Mei-Chiung Shih
Institutions
- VA Palo Alto Health Care System (US)
- University of Utah (US)
- VA Salt Lake City Healthcare System (US)
- The Coordinating Center (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- JAMA Ophthalmology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1001/jamaophthalmol.2025.6262
- Citations
- 1
- Primary Topic
- Intraoperative Neuromonitoring and Anesthetic Effects
- Type
- article
- Field-Weighted Citation Impact
- 39.15
Funders
- U.S. Department of Veterans Affairs
- AstraZeneca
- Celgene
- National Institutes of Health