Delineating the trajectory of adult chronic diseases and healthcare use for 22q11.2 microdeletion in a general population context
A population-based approach provided new evidence for accumulating illnesses over young adulthood, supporting the need for novel models of anticipatory care for adults with 22q11.2 microdeletion. A similar genetics-first strategy, defining cohorts with shared genetic changes, may facilitate understanding of premature aging mechanisms relevant to the general population.
Authors
- Eyal Cohen (ORCID: https://orcid.org/0000-0003-0112-7188)
- Thérèse A. Stukel (ORCID: https://orcid.org/0000-0002-2951-1360)
- Sarah Malecki (ORCID: https://orcid.org/0000-0003-3457-0696)
- Samantha Steffnny da Costa Morais
- Anne S. Bassett
- Tracy Heung
- Refik Saskin
- Drew Wilton
- Amol A. Verma
Institutions
- St. Michael's Hospital (CA)
- University Health Network (CA)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Toronto General Hospital (CA)
- Institute of Health Services and Policy Research (CA)
- Institute for Clinical Evaluative Sciences (CA)
- St Michael's Hospital (GB)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fgene.2026.1737027
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Ontario
- Physicians' Services Incorporated Foundation
- Canadian Institutes of Health Research