Causal effects of reproductive traits on cognitive function: A two‐sample and multivariable mendelian randomization study
Our UVMR and MVMR analyses provide evidence that earlier AFS and earlier AFB are risk factors for cognitive decline. The protective effect of oral contraceptive pills and fewer number of live births on cognitive function is partly influenced by EA. These findings emphasize the important role of reproductive traits in influencing cognitive function.
Authors
- X Wang
- Yunyun Guo (ORCID: https://orcid.org/0009-0009-4572-1139)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- MRC Unit for Lifelong Health and Ageing (GB)
- Imperial College London (GB)
Publication Details
- Journal
- International Journal of Gynecology & Obstetrics
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1002/ijgo.70875
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00