Exploration and discovery of treatment targets for primary biliary cholangitis based on plasma and cerebrospinal fluid proteomics: A multicenter mendelian randomization study
Elevated plasma MANBA and CSF TNFSF15 levels were linked to increased PBC risk, while higher plasma FCRL3 was protective. Our findings nominate MANBA and TNFSF15 as potential therapeutic targets, while FCRL3 may serve as a protective biomarker for PBC management.
Authors
- Zhongqi Fan
- James Law (ORCID: https://orcid.org/0000-0002-4966-3556)
- Jianxin Xi
- Guan Huei Lee (ORCID: https://orcid.org/0000-0002-8652-6403)
- Guoyue Lv
- Jie Chen
- Shengnan Wang
- Jianglong Wang
- Yuguo Chen
Institutions
- Union Hospital (HK)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- National University Hospital (SG)
- Huazhong University of Science and Technology (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1371/journal.pone.0340166
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00