Baseline glucose-to-lymphocyte ratio predicts nivolumab outcomes in advanced non-small cell lung cancer: a multicenter retrospective study
Baseline GLR is a practical, cost-effective biomarker that independently predicts OS in advanced NSCLC patients treated with nivolumab. Elevated GLR likely reflects metabolic dysfunction and impaired immune reserve, both unfavorable for PD-1 blockade efficacy. Prospective studies are warranted to validate GLR and define its role in clinical decision-making.
Authors
- Teoman Şakalar (ORCID: https://orcid.org/0000-0003-2749-9414)
- Sedat Yıldırım (ORCID: https://orcid.org/0000-0002-2423-6902)
- Ertuğrul Bayram (ORCID: https://orcid.org/0000-0001-8713-7613)
- muslih urun
- Pervin Can Şancı
- Hayati Arvas (ORCID: https://orcid.org/0000-0003-2215-5567)
- Gözde Ağdaş (ORCID: https://orcid.org/0000-0001-9771-6483)
- Sedat Biter (ORCID: https://orcid.org/0000-0002-1053-0668)
- Muhammet Cengiz (ORCID: https://orcid.org/0000-0002-2028-9687)
- Duygu Bayir
- Mehmet Haluk Yücel (ORCID: https://orcid.org/0000-0001-6880-7204)
- Erdem Kolemen
- Ayse Nuransoy Cengiz
- Devrim Cabuk
- Havva Yesil Cinkir
- Umut Kefeli
- Canan Yıldız
- Mustafa Ersoy
- Berrak Mermeit
- Ezgi Turkoglu
- Anil Karakayalı
- Erkam Kocaaslan
- Elif Sahin
- Mehmet Mutlu
- Emel Mutlu
Institutions
- Van Yüzüncü Yıl Üniversitesi (TR)
- Dicle University (TR)
- Yozgat Bozok Üniversitesi (TR)
- University Medical Center (US)
- Istanbul Medipol University (TR)
- Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Hastanesi (TR)
- İstanbul Eğitim ve Araştırma Hastanesi (TR)
- Hitit Üniversitesi Çorum Eğitim ve Araştırma Hastanesi (TR)
- Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR)
- Ministry of Food Agriculture and Livestock (TR)
- Kahramanmaraş Sütçü İmam University (TR)
- Kocaeli Üniversitesi (TR)
- Afyon Kocatepe University (TR)
- Cukurova University (TR)
- Gaziantep University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fimmu.2026.1714533
- Citations
- 1
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 24.20