Causal relationships between 41 inflammatory cytokines and myopia: a Mendelian randomization study

This study provides evidence supporting a causal relationship between specific inflammatory cytokines and myopia. MIP-1α may act as a protective factor against myopia, while eotaxin, SDF-1α, and IL-2Rα are potential risk factors for myopia. These findings emphasize the critical role of inflammatory pathways in the pathogenesis of myopia, offering novel insights for the development of preventive and therapeutic strategies for myopia.

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Publication Details

Journal
International Journal of Ophthalmology
Published
2026-02-12
DOI
https://doi.org/10.18240/ijo.2026.03.19
Primary Topic
Ophthalmology and Visual Impairment Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Causal relationships between 41 inflammatory cytokines and myopia: a Mendelian randomization study

Lian-Yi Sun, Xiao-Fei Wu, Rui Li, Shuang Li et al.
International Journal of Ophthalmology
Ophthalmology and Visual Impairment Studies
article

Causal relationships between 41 inflammatory cytokines and myopia: a Mendelian randomization study

Lian-Yi Sun, Xiao-Fei Wu, Rui Li, Shuang Li, YING ZHANG
article en

Abstract

This study provides evidence supporting a causal relationship between specific inflammatory cytokines and myopia. MIP-1α may act as a protective factor against myopia, while eotaxin, SDF-1α, and IL-2Rα are potential risk factors for myopia. These findings emphasize the critical role of inflammatory pathways in the pathogenesis of myopia, offering novel insights for the development of preventive and therapeutic strategies for myopia.

International Journal of OphthalmologyVol. 19(3)
Northwest University (CN), Shanxi Eye Hospital (CN)
University of Bristol
Reduced inequalities
Openalex Percentile: Top 58%
Ophthalmology and Visual Impairment Studies
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