Supplemental exposure to polystyrene nanoplastics synergistically amplifies calcium oxalate crystal–induced injury to renal tubular epithelium, accelerating the formation of calcium oxalate kidney stones
Our study identifies PS-NPs as novel lithogenic cofactors that promote CaOx nucleation, enhance crystal adhesion to renal tubular epithelial cells, and amplify inflammation and ferroptosis through LRP6 downregulation. This suggests that microplastic pollution may be an emerging environmental risk factor for kidney stone pathogenesis.
Authors
- Yi Yang (ORCID: https://orcid.org/0000-0002-4091-8532)
- Caitao Dong (ORCID: https://orcid.org/0000-0003-0003-9135)
- Mengmeng Shi (ORCID: https://orcid.org/0000-0003-2472-3783)
- Heng Xiang (ORCID: https://orcid.org/0000-0001-5967-872X)
- Sixing Yang (ORCID: https://orcid.org/0000-0002-4397-4484)
- Yunhe Xiong (ORCID: https://orcid.org/0000-0001-6922-3593)
- Xiaozhe Su (ORCID: https://orcid.org/0000-0002-7407-944X)
- Ziqi He (ORCID: https://orcid.org/0000-0002-0439-1390)
- Qinhong Jiang
- Bobo Chen
- Yunhan Wang
- Qixuan Zhou
- Qianlin Song
Institutions
- China University of Geosciences (CN)
- Wuhan University (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Renmin Hospital of Wuhan University (CN)
- Hubei University (CN)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s12989-026-00661-0
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00