Nocardia rubra cell wall skeleton-induced MARCO expression: implications for improved phagocytosis and cytokine secretion in tumor-associated macrophages
The study demonstrates that Nr-CWS enhances TAM anti-tumor immune function via MARCO upregulation, leading to improved phagocytic activity and proinflammatory response. These findings align with genomic and cellular evidence, suggesting MARCO as a key mediator in Nr-CWS-induced macrophage reprogramming, with implications for HPV-related neoplasia immunotherapy.
Authors
- Wenxing Chen (ORCID: https://orcid.org/0000-0001-9669-4358)
- Yan Zheng (ORCID: https://orcid.org/0000-0003-4877-7292)
- Qianyu Guo (ORCID: https://orcid.org/0009-0001-2548-3921)
- Xue Bai (ORCID: https://orcid.org/0000-0002-2040-7778)
- Xiaomin Dong
- Suxia Shao
- Guiyuan Zhou
- Lei Zhang
Institutions
- Hebei Medical University (CN)
- Shijiazhuang University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fimmu.2026.1611476
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00