Remimazolam alleviates acute lung injury by inhibiting ferroptosis: a multi-omics system pharmacology approach with experimental validation
This study demonstrated that REM alleviated LPS-induced lung injury by inhibiting ferroptosis, potentially through upregulation of HO-1 and restoration of the SLC7A11-GSH-GPX4 axis. These findings provide novel mechanistic insights into the anti-ferroptotic effects of REM and highlight its therapeutic potential in ALI/ARDS management.
Authors
- J. LI
- Lingzhi Qin Qin
- Ruohan Li (ORCID: https://orcid.org/0009-0000-7961-0087)
- Chuchu Zhang
- Guorong Deng
- Ya Gao
- Jiajia Ren
- Jingjing Zhang
- Gang Wang
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s40001-026-03997-7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00