Cognitive function is associated with the progression of non-tremor motor symptoms in Parkinson’s disease

Global cognition at baseline is associated with the progression, but not severity, of motor impairment in PD; this finding is specific to non-tremor and not tremor motor symptoms. While both motor subdomains are known to be linked with dysfunction of sub-cortical circuits, non-tremor symptoms may also be influenced by disrupted cognitive inputs. Our results highlight the potential value of incorporating cognitive tools to complement motor examination in PD assessment.