Differential genome-wide association analysis of schizophrenia and post-traumatic stress disorder identifies opposing effects at the MAPT/CRHR1 locus

These findings provide evidence for distinct and opposing genetic contributions to SCZ and PTSD. The identification of the <i>MAPT</i>/<i>CRHR1</i> locus with brain-region-specific and gene-specific regulatory effects highlights divergent neurodevelopmental and stress-related pathways underlying these disorders.