PRIP/PLCL deficiency activates PI3K–AKT–YAP signaling and promotes organ fibrosis
PRIP/PLCL deficiency mediates YAP activation via the PI3K-AKT-MST2 axis, thereby accelerating fibroblast activation and organ fibrotic remodeling. Collectively, PRIP/PLCL acts as a novel anti-fibrotic factor, and restoring its activity could be an effective therapeutic approach for treating fibrotic diseases.
Authors
- Tomomi Sano (ORCID: https://orcid.org/0000-0001-8342-0315)
- Meiqun Yuan
- Akiko Mizokami (ORCID: https://orcid.org/0000-0002-7490-5190)
- T Kanematsu
- Jing Gao
Institutions
- Kyushu University (JP)
- Kyushu Dental University (JP)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s12964-026-02717-2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00