Rational Combination of Dominant and Subdominant Antigens with Nanoadjuvant Elicits Durable Immunity Against Staphylococcus aureus
This study demonstrates that rational combination of immunodominant and subdominant antigens with a compatible nanoadjuvant induces synergistic and durable immunity against <i>S. aureus.</i> This co-design strategy addresses key limitations of previous vaccines and provides a promising foundation for future clinical development.
Authors
- Li Fan
- Jiayue Xi
- Qian Yang (ORCID: https://orcid.org/0000-0003-4401-1257)
- Zhuo Wan (ORCID: https://orcid.org/0000-0003-3202-2776)
- Zhengjun Ma (ORCID: https://orcid.org/0009-0002-5099-5934)
- Xin He
- Dong Wang
- Yupu Zhu
- Muqiong Li
- Yufei Hou
- Nan Sun
- Minxuan Cui
- Zhuoyue Shi
Institutions
- Northwestern Polytechnical University (CN)
- Joint Institute for Nuclear Research (RU)
- Air Force Engineering University (CN)
- Ministry of Education (KR)
- Tang Du Hospital (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3390/vaccines14020169
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00