Performance of the Self‐Controlled Case Series for Drug Safety Signal Detection: A Multi‐Database Study
Using a carefully designed reference set of drug-outcome pairs well suited to the study design, the SCCS performance varied substantially by database due to differences in population, reporting, healthcare and coding systems and prescribing patterns. Multi-database studies showed increased performance of SCCS for signal detection.
Authors
- François Haguinet (ORCID: https://orcid.org/0000-0003-4989-3738)
- Astrid Coste (ORCID: https://orcid.org/0000-0003-4207-7447)
- Andrew Bate
- Angel Y. S. Wong
- Ian J. Douglas
Institutions
- London School of Hygiene & Tropical Medicine (GB)
- Center for Non-Communicable Diseases (PK)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/pds.70298
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- GlaxoSmithKline