Pathophysiology of androgen-associated endothelial cell dysfunction in phenotype A polycystic ovarian syndrome revealed by iPSCs modeling

In conclusion, disease-specific iPSCs were successfully generated from phenotype A PCOS patients, providing a robust platform for disease modeling in this distinct subgroup. PCOS iPSC-derived ECs exhibited significantly impaired intrinsic and androgen-induced cell proliferation and angiogenesis. These findings offer novel mechanistic insights into endothelial dysfunction in PCOS and suggest potential implications for increased cardiovascular risk in affected individuals.