Orthopedic manifestations as presenting symptoms in children with neuroblastoma: a retrospective case series and clinical review

Approximately one-fifth of children with neuroblastoma initially present to orthopedic surgeons. Persistent or atypical musculoskeletal complaints-especially hip pain or back pain accompanied by anemia, high ESR, or high CRP-should prompt the consideration of neuroblastoma and early histopathological evaluation to avoid diagnostic delays.