Cell Type‐Specific Loss of <scp>SIRT1</scp> in Central Amygdala Leads to Depression‐Like Behaviors by Altering Neuronal Excitability in Mice
Our findings indicate that cell-type-specific loss of SIRT1 may mediate the development of depression-like behaviors in mice by divergent changes in the excitability of CeA glutamatergic and GABAergic neurons. These data demonstrate a new mechanism for the development of depression and provide a potential therapeutic target for depression.
Authors
- Chenghua Zhou (ORCID: https://orcid.org/0000-0001-9879-8679)
- Tian‐Qi Chen
- Xiao‐Bao Ding
- Hui Huang (ORCID: https://orcid.org/0000-0002-4741-4361)
- Yuqing Wu (ORCID: https://orcid.org/0000-0002-7376-4971)
- Yu‐Wen Lin
- Chen‐Rui Zhou
- Wei Dong
- Wen‐Li Hu
- Yue Zhou
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1111/apha.70176
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 27.18