Association of Circulating T Cell and Tumor Microenvironment Profiles with Immune Checkpoint Blockade Outcomes in Sarcoma
Sarcoma patients with a PRO circulating T cell immunotype had inferior outcomes to ICB, while those with an immune-enriched/non-fibrotic TME had superior outcomes. Automated analysis of H&E slides showed promise in identifying patients with an immune-enriched TME. These findings support utilization of a multimodal approach toward identifying predictors of response to immunotherapy in sarcoma.
Authors
- Jasme Lee (ORCID: https://orcid.org/0009-0006-4492-4872)
- Paige Fuentes (ORCID: https://orcid.org/0000-0003-4868-9030)
- Mohammad Yosofvand (ORCID: https://orcid.org/0000-0002-7733-2236)
- A. Subramanian
- Paige Collins
- Lauren B. Banks (ORCID: https://orcid.org/0000-0002-3443-6414)
- Ping Chi
- Everett J. Moding (ORCID: https://orcid.org/0000-0001-7913-5351)
- Damon R. Reed (ORCID: https://orcid.org/0000-0002-8238-2465)
- О. Yu. Baranov (ORCID: https://orcid.org/0000-0002-0665-0093)
- Mrinal M. Gounder (ORCID: https://orcid.org/0000-0001-8468-0119)
- K. Panageas
- Jason E. Chan (ORCID: https://orcid.org/0000-0003-0552-8544)
- Mark A. Dickson (ORCID: https://orcid.org/0000-0003-2764-751X)
- Evan Rosenbaum (ORCID: https://orcid.org/0000-0002-7499-1279)
- W. Tap
- Martina Bradić (ORCID: https://orcid.org/0000-0001-6078-5311)
- Sujana Movva (ORCID: https://orcid.org/0000-0002-6569-6606)
- Allison Reiner (ORCID: https://orcid.org/0009-0008-4150-6856)
- Konstantin Chernyshov
- Mathew Adamow
- Sandra P. D’Angelo (ORCID: https://orcid.org/0000-0002-3736-3783)
- Nikita Kotlov (ORCID: https://orcid.org/0000-0002-6393-7357)
- Fiona Ehrich (ORCID: https://orcid.org/0000-0002-2245-9352)
- Rhoena Desir (ORCID: https://orcid.org/0009-0001-7607-1521)
- Mary Lou Keohan
- C. Antonescu
- Phillip Wong
- Li-Xuan Qin
- Viswatej Avutu
- Ciara M. Kelly
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Stanford Medicine (US)
- Repligen (United States) (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3419
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00