Brain texture alterations predict subtle visual perceptual dysfunctions in recent onset psychosis and clinical high-risk state

Deeper understanding of Subtle Visual Dysfunctions (VisDys) in the early stage of mental illness and their neurobiological underpinnings, as reflected by microstructural brain texture features, could advance our understanding of the underlying disease perceptual mechanisms that mediate susceptibility to psychosis. In this study, we aim a) to investigate the utility of brain texture features for the prediction of VisDys in recent onset psychosis (ROP) and clinical high-risk syndromes for psychosis (CHR-P), respectively, b) to test prediction models established in ROP and CHR-P in an independent validation sample with recent onset depression (ROD) diagnoses and c) to test for symptom expression related brain features associated with VisDys. sMRI were acquired in a training sample including 128 ROP (67 patients with VisDys), 134 CHR-P (71 patients with VisDys). Independent validation sets included 46 ROP (19 with VisDys), 124 CHR-P (68 patients with VisDys) and a sample of 256 ROD (50 patients with VisDys). Both classification schemas in ROP and CHR-P presented balanced accuracy >77% and >64% in the independent validation samples of ROP, CHR-P, and ROD, respectively. Statistically significant associations were identified with scores from the Positive and Negative Symptom Scale, psychosocial functioning, and the Scale of Negative Symptoms.

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Journal
Translational Psychiatry
Published
2026-02-12
DOI
https://doi.org/10.1038/s41398-026-03840-x
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Brain texture alterations predict subtle visual perceptual dysfunctions in recent onset psychosis and clinical high-risk state

Leonardo Fazio, Marian Surmann, Otto Turtonen, Inga Meyhöfer et al.
Translational Psychiatry
Schizophrenia research and treatment
article

Brain texture alterations predict subtle visual perceptual dysfunctions in recent onset psychosis and clinical high-risk state

Leonardo Fazio, Marian Surmann, Otto Turtonen, Inga Meyhöfer, F. Schultze-Lutter, Martina Wassen, Georg Romer, Mirabel Pelton, Laura J. Egloff, Yanis Köhler, Maria Fernanda Urquijo-Castro, Amatya Mackintosh, Anna Toivonen, Paris Alexandros Lalousis, Stephan Ruhrmann, Raffaella Romano, A. Schmidt, Pavan Mallikarjun, Marian Surman, Αλεξάνδρα Κορδά, Lisa Hahn, Antonia Wosgien, J. Wenzel, Carlo Altamura, Nathalie Kaiser, Henri Pesonen, F. Fabbro, Ashleigh Peng Lin, Francesca Bottinelli, Adrian Rangnick, Shalaila S. Haas, Andreas Sprenger, Dennis M. Hedderich, Letizia Leanza, Andrea Falsetti, S. Piccin, Sonja Widmayer, Camilla Krämer, Anna Walter, Sonja Botterweck, Ana Beatriz Solana, Dominika Julkowski, Linda A. Antonucci, Marlene L. Rosen, Marika Belleri, Maria Nobile, Alexandra Stainton, Renata Smieskova, R Milz, Julian Caspers, Rebekka Lencer, Hans-Jörg Wittsack, Marta Lo Re, Lorenzo Del Fabro, C. Bonivento, M. Balestrieri, C. Andreou, D. Popovic, Rachel Upthegrove, Nora Penzel, Anne Ruef, Rachele Sanfelici, Tiina From, Timo Schirmer, Christos Davatzikos, Päivi Jalo, Susanne Neufang, Adele Ferro, Karsten Blume, Grazia Caforio, Stephen J. Wood, Marco Garzitto, Giuseppe Blasi, Henrik Rohner, Aylin Melo, Ulrike Heitz, Christian Schmidt-Kraepelin, Thorsten Lichtenstein, Mauro Seves, Marina Barone, Mariam Iqbal, Joseph Kambeitz, Janina Paju, Claudius Hoff, Pierluigi Selvaggi, Barbara Gelao, Udo Dannlowski, Markus Heinimaa, Alexandra Nikolaides, Paolo Brambilla, Alessandro Bertolino, Reetta-Liina Säilä, Susanna Muckenhuber-Sternbauer, Johanna Weiske, Roberta Passiatore, Theresa Lichtenstein, Anita Riecher-Rössler, Sebastian von Saldern, Fabienne Harrisberger, Lana Kambeitz-Ilankovic, Heikki Laurikainen, Andrea Falsetti, Sian Lowri Griffiths, Tiziana Quarto, Stefan Borgwardt, Chris Day, Nikolaos Koutsouleris, Eva Meisenzahl, Alexander Denissoff, Jarmo Hietala, Ömer Öztürk, Anu Ellilä, Giulio Pergola, Alessandra Alciati, Norman Kluthausen, Moritz Spangemacher, Claudia Lenz, Christos Pantelis, Ana Tupac
article en

Abstract

Deeper understanding of Subtle Visual Dysfunctions (VisDys) in the early stage of mental illness and their neurobiological underpinnings, as reflected by microstructural brain texture features, could advance our understanding of the underlying disease perceptual mechanisms that mediate susceptibility to psychosis. In this study, we aim a) to investigate the utility of brain texture features for the prediction of VisDys in recent onset psychosis (ROP) and clinical high-risk syndromes for psychosis (CHR-P), respectively, b) to test prediction models established in ROP and CHR-P in an independent validation sample with recent onset depression (ROD) diagnoses and c) to test for symptom expression related brain features associated with VisDys. sMRI were acquired in a training sample including 128 ROP (67 patients with VisDys), 134 CHR-P (71 patients with VisDys). Independent validation sets included 46 ROP (19 with VisDys), 124 CHR-P (68 patients with VisDys) and a sample of 256 ROD (50 patients with VisDys). Both classification schemas in ROP and CHR-P presented balanced accuracy >77% and >64% in the independent validation samples of ROP, CHR-P, and ROD, respectively. Statistically significant associations were identified with scores from the Positive and Negative Symptom Scale, psychosocial functioning, and the Scale of Negative Symptoms.

Translational PsychiatryVol. 16(1)
University of Bern (CH), University of Udine (IT), University of Turku (FI), University of Cologne (DE), King's College London (GB), University of Basel (CH), University of Milan (IT), Universitas Airlangga (ID), University of Münster (DE), Florey Institute of Neuroscience and Mental Health (AU), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), University of Oxford (GB), Düsseldorf University Hospital (DE), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT), Ospedale San Paolo (IT), GE Global Research (United States) (US), Max Planck Institute of Psychiatry (DE), IRCCS Eugenio Medea (IT), University Hospital Cologne (DE), Birmingham Women’s and Children’s NHS Foundation Trust (GB), Melbourne Health (AU), Heinrich Heine University Düsseldorf (DE), University of Bari Aldo Moro (IT), Monash University (AU), FH Münster University of Applied Sciences (DE), University of Pennsylvania (US), University of Birmingham (GB), Ludwig-Maximilians-Universität München (DE), University of Lübeck (DE), Icahn School of Medicine at Mount Sinai (US)
Universität zu Lübeck, European College of Neuropsychopharmacology
Openalex Percentile: Top 61%
Schizophrenia research and treatment
DOIOpen Access PDFOpenAlex
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